Introduction of Resveratrol
trans-Resveratrol is a naturally occurring stilbenoid polyphenol renowned for its potent antioxidant and sirtuin-activating properties. Our natural trans-Resveratrol is primarily extracted from the knotwood of Japanese knotweed (Polygonum cuspidatum Sieb. et Zucc., also known as Fallopia japonica), which contains the highest naturally occurring concentration of trans-resveratrol among edible plants. We utilize a proprietary green ethanol-water gradient extraction system followed by macroporous resin adsorption chromatography, simulated moving bed (SMB) purification, and recrystallization technology. The final product achieves ≥98% trans-resveratrol purity (HPLC) with ultra-low cis-isomer content (<0.5%) and emodin-free (<10 ppm), fully compliant with USP, EP, and JP pharmacopoeia standards as well as global nutraceutical and cosmetic requirements.
Differentiated advantages: Unlike synthetic resveratrol (which often contains cis-isomers and residual palladium catalysts from chemical synthesis), our natural plant-derived product is exclusively the bioactive trans isomer with >99% stereoisomeric purity. Compared to resveratrol from grape skin or red wine extracts (typically 1–5% purity), our Polygonum cuspidatum source provides 50–100x higher yield with consistent quality. Our proprietary emodin removal technologyensures undetectable levels of emodin (a natural anthraquinone with laxative and potential genotoxic concerns), making our product safer for long-term use. Additionally, we use pollution-free raw materials from controlled cultivation bases, not wild-harvested roots, ensuring ecological sustainability and heavy metal control.
Key Active Compounds
The core active compound is trans-Resveratrol (trans-3,5,4′-trihydroxystilbene) (CAS: 501-36-0, molecular formula C₁₄H₁₂O₃, molecular weight 228.25). As a stilbenoid phytoalexin, resveratrol is produced by plants in response to stress, injury, or fungal infection. The trans isomer is the naturally predominant and biologically active form, while the cis isomer has significantly lower activity. Our product contains ≥98% trans-resveratrol (HPLC) with cis-isomer strictly controlled at ≤0.5%, and related substances (resveratroloside, piceid, emodin, polydatin) each below detectable or specification limits. This high stereoisomeric purity ensures maximum bioavailability, target engagement (sirtuins, COX-1/2, aromatase), and batch-to-batch consistency.
Benefits
Sirtuin Activation & skin wellness support: Directly activates SIRT1 (NAD+-dependent deacetylase) at physiologically relevant concentrations (EC50 ~5 µM), mimicking caloric restriction. Extends cellular lifespan, delays age-related decline, improves mitochondrial biogenesis and function, and reduces cellular senescence.
Powerful Antioxidant & Free Radical Scavenger: Neutralizes ROS (reactive oxygen species) and RNS (reactive nitrogen species) including hydroxyl radicals, superoxide, peroxynitrite, and lipid peroxyl radicals. Protects DNA, proteins, and lipids from oxidative damage. Upregulates endogenous antioxidant enzymes (SOD, catalase, GPx, glutathione) via Nrf2 pathway activation.
Cardiovascular Protection (The “French Paradox” Molecule): Improves endothelial nitric oxide synthase (eNOS) activity, increases NO production, promotes vasodilation and healthy blood pressure. supports lipid balance, inhibits platelet aggregation, decreases vascular inflammation, prevents vascular wellness, and reduces myocardial ischemia-reperfusion injury. Clinically studied for heart failure, blood-pressure related, and peripheral artery disease.
& Chemoprevention: Inhibits at initiation, promotion, and progression stages. Induces in cells (p53-dependent and independent pathways), arrests cell cycle at G1/S and G2/M checkpoints, inhibits angiogenesis (VEGF downregulation), and suppresses (MMP inhibition). Effective against breast, prostate, colon, pancreatic, cervical, and cells with minimal toxicity to normal cells.
Neuroprotection & Cognitive Health: Crosses the blood-brain barrier (BBB), reduces amyloid-beta aggregation and tau hyperphosphorylation (Alzheimer’s hallmarks), activates AMPK and autophagy for clearance of misfolded proteins, reduces neuroinflammation (microglial activation), supports brain wellness. Shows promise for cognitive support��s, ��s, and cognitive support.
Anti-Inflammatory & Immunomodulation: Inhibits NF-κB activation (IC50 ~7 µM), suppresses pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8), downregulates COX-2 and iNOS expression, reduces PGE2 and NO production. Clinically effective for arthritis, inflammatory bowel disease, and chronic systemic inflammation.
Metabolic & Longevity Benefits: Activates AMPK, improves insulin sensitivity, reduces blood glucose and HbA1c. Increases adiponectin, reduces fatty liver (hepatic steatosis), promotes white adipose tissue browning, improves lipid profile (LDL↓, HDL↑, triglycerides↓). Extends healthspan and lifespan in multiple model organisms (yeast, C. elegans, flies, fish, rodents).
Typical Specification Sheet
| Item | Specification | Test Method |
|---|---|---|
| Product Name | Natural trans-Resveratrol | Visual / TLC |
| Active Component | trans-Resveratrol ≥98.0% (or ≥99.0%) | HPLC (USP/EP method) |
| CAS Number | 501-36-0 | Chemical Analysis |
| Molecular Formula | C₁₄H₁₂O₃ | Chemical Analysis |
| Molecular Weight | 228.25 | Chemical Calculation |
| Appearance | White to off-white fine powder | Visual & Organoleptic |
| Identification (IR/HPLC RT) | Conforms to reference standard | FT-IR / HPLC |
| trans/cis Isomer Ratio | trans ≥99.5%, cis ≤0.5% of total resveratrol | HPLC-PDA |
| Loss on Drying | ≤1.0% | USP <731> |
| Residue on Ignition | ≤0.2% | USP <281> |
| Assay (anhydrous basis) | 98.0% – 101.0% | HPLC (external standard) |
| Related Substances | Emodin: Not detectable (<10 ppm), Polydatin: ≤0.1%, Piceid: ≤0.1% | HPLC |
| Residual Solvents | Ethanol ≤500 ppm; Methanol ≤300 ppm; Ethyl acetate ≤500 ppm | GC |
| Heavy Metals | Total ≤10 ppm (Pb ≤0.5 ppm, As ≤0.5 ppm, Cd ≤0.5 ppm, Hg ≤0.1 ppm) | ICP-MS |
| Pesticides | Conforms to USP <561> (none detected) | GC-MS/MS |
| Microbial Limits | TPC ≤1000 CFU/g; Yeast/Mold ≤100 CFU/g; E. coli/Salmonella: Negative | USP <61> / <62> |
| Bulk Density | 0.3 – 0.6 g/mL | USP <616> |
| Particle Size | 100% through 80 mesh; optional micronized (D90 <20 µm) | Sieve / Laser diffraction |
| Storage | Cool, dry, airtight, protected from light (UV degradation) | N/A |
| Shelf Life | 36 months from date of manufacture (under proper storage) | ICH stability study |
Application Cases
Pharmaceutical Field: Studied as a research compound in research on metabolic wellness, Alzheimer’s disease (phase II), cardiovascular research, and wellness research. Used in compounding pharmacies for customized sirtuin-activation protocols. Also used as a reference standard in analytical testing.
Dietary Supplement Field: Premium ingredient in topical formulations (with NMN, pterostilbene, spermidine, TMG), cardiovascular health capsules, NAD+ booster stacks, joint health formulas (with glucosamine, chondroitin, boswellia), and metabolic support blends. Available as bulk powder for capsules, tablets, gummies, sublingual lozenges, and liquid shots. Exported to over 60 countries including USA, EU, Japan, South Korea, Australia, and Brazil.
Cosmetics Field: Star ingredient in skin wellness support serums, moisturizers, eye creams, sunscreens (photoprotection), night repair masks, and post-procedure calming formulations. Valued for its ability to activate SIRT1 in skin fibroblasts, boost collagen synthesis, reduce UV-induced MMP expression, lighten hyperpigmentation, and reduce redness/inflammation. Stable in lipid-based and encapsulated delivery systems.
Functional Food & Beverage Field: Added to functional beverages (red wine alternatives, wellness shots, ready-to-drink teas), protein bars, chocolates, chewing gums, and fortified water. Used as a natural preservative due to its antioxidant and antimicrobial properties. Nano-emulsion and liposomal formulations enhance bioavailability in liquid applications.
Research Field: Widely used as a positive control and standard for SIRT1 activation assays, antioxidant studies, skin wellness support research, wellness biology, and neuroprotection studies. Available in research-grade (≥98%) and reference-standard (>99.5%) purity.
Why Choose Us
Controllable Raw Materials: Our Japanese knotweed is sourced exclusively from GAP-certified cultivation bases in China (Zhangjiajie and Qinling Mountains). Plants are harvested at optimal season (fall of 2nd year) when knotwood trans-resveratrol content peaks (4–6%). No wild collection, no pesticide overuse. Raw materials are 100% traceable and certified emodin-free at source through variety selection (low-emodin chemotype Polygonum cuspidatum).
Advanced Green Technology: Proprietary three-stage process: (1) Gradient ethanol-water extraction (30–80% ethanol) at low temperature (40°C) minimizes isomerization and degradation; (2) Simulated moving bed chromatography removes cis-isomer, emodin, polydatin, and resveratroloside; (3) Triple recrystallization in food-grade ethanol + deionized water achieves >99% trans-purity. No dichloromethane, chloroform, or hexane used. Solvent recovery rate >95%, environmentally sustainable.
Stringent Quality Control: cGMP-compliant production (class 100,000 cleanroom). Every batch undergoes full HPLC-DAD analysis for trans/cis ratio, emodin (LOD 2 ppm, LOQ 5 ppm), polydatin, related substances, residual solvents (GC), heavy metals (ICP-MS), and microbial testing. Stability chambers monitor 36-month shelf life (conditions: 25°C/60% RH and 40°C/75% RH per ICH Q1A). Third-party validation available (SGS, Eurofins, Intertek).
Regulatory Compliance: Manufactured under ICH Q7 GMP guidelines for pharmaceutical intermediates. USP/EP compendial compliance. Complete documentation: COA, MSDS (GHS format), allergen statement (free from major allergens), Non-GMO statement, Kosher certificate (OU or OK), Halal certificate, TSE/BSE-free, gluten-free, irradiation-free, and residual solvent declaration. Support for NDI (New Dietary Ingredient) filing and Drug Master File (DMF) preparation.
Rich Export Experience: 15+ years of exporting natural trans-resveratrol to global pharmaceutical and nutraceutical markets. Expert knowledge of HS code 2932.99, US FDA import alerts (including Green List status for our facility), EU Novel Food compliance (resveratrol authorized under Regulation (EU) 2017/2470), and Japan FOSHU applications. Reliable logistics with temperature-controlled shipping (20–25°C, avoid >40°C) and double-laminated aluminum foil bags + HDPE drums for light/oxygen protection.
Professional Service & Competitive Pricing: In-house PhD team for custom specifications (micronization, encapsulation, liposome pre-dispersion, co-crystals with piperine or cyclodextrins), stability testing support, and regulatory filing assistance. Integrated vertical supply chain (plantation → extraction → purification → packaging) eliminates 3+ intermediaries, offering USP-grade trans-resveratrol at 30–40% below industry average for comparable purity. 24/7 technical support and post-sales quality assurance. Free samples (10–20g) available for qualified partners.
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
