Overview
Luteolin (3',4',5,7-tetrahydroxyflavone, CAS 491-70-3) is a naturally occurring flavone found in many edible and medicinal plants. GreeneryBio supplies pharmaceutical-grade Luteolin extracted from GAP-certified botanical sources — primarily Chrysanthemum morifolium (chrysanthemum), Perilla frutescens (perilla), and Sophora japonica (Japanese pagoda) — with full traceability and strict freedom from heavy metals, pesticide residues, and microbial contaminants.
Our material is available in three HPLC-verified purity grades:
- Standard: ≥95.0%
- High Purity: ≥98.0%
- Premium: ≥99.5% (suitable for pharmaceutical and clinical research)
All batches comply with USP/EP analytical methods and ICH Q3C solvent-residue limits.
Raw Material & Extraction
We employ a green, multi-stage purification technology:
- Pretreatment — low-temperature drying and micronization of botanical material to maximize extraction efficiency.
- Extraction — ultrasound-assisted ethanol extraction (300 W, 40 min) or supercritical CO₂ extraction (35 MPa, 45 °C).
- Purification — solvent defatting, AB-8 macroporous-resin adsorption, preparative HPLC on C18 reverse-phase column, and recrystallization in a methanol-water system.
- Final processing — vacuum drying and sterile packaging yield a stable crystalline product.
This process minimizes structural analogs (apigenin, kaempferol) below 0.5% in our High Purity grade, eliminating a common cross-reactivity headache in HPLC assays.
Health Benefits & Mechanisms
Potent anti-inflammatory activity
- Inhibits NF-κB, MAPK (JNK/p38), and STAT3 pathways
- Reduces TNF-α, IL-6, and NO production in activated macrophages
- Suppresses mast cell degranulation and histamine release, useful in anti-allergy formulations
Antioxidant defense
- Scavenges DPPH, ABTS, and hydroxyl radicals (DPPH IC₅₀ ≈ 15.3 μM)
- Activates the Nrf2 / ARE / HO-1 pathway, upregulating endogenous antioxidant enzymes
- Protects cells from oxidative DNA damage
Neuroprotection
- Mitigates β-amyloid aggregation and tau hyperphosphorylation in cognitive-health models
Cardiovascular support
- Improves lipid metabolism via the retinoic-acid–PPAR axis
- Inhibits vascular inflammation and oxidative stress
- Reduces foam-cell formation, contributing to anti-atherosclerotic activity
Additional benefits
- Uric acid lowering through xanthine oxidase inhibition
- Skin — soothes sensitive skin, reduces redness, supports skin wellness formulations
Applications
Nutraceuticals & dietary supplements
- Anti-inflammatory and joint-health capsules/tablets
- Cardiovascular blends with resveratrol and omega-3
- Cognitive-health stacks
Cosmetics & personal care
- Sensitive-skin creams and serums (reduces redness)
- topical formulations leveraging antioxidant and collagen-protecting effects
- Brightening products (inhibits melanin synthesis)
Pharmaceutical R&D
- Anti-inflammatory drug candidates for chronic inflammatory disease
- Respiratory therapies under investigation
Functional foods & beverages
- Health drinks, herbal teas, and fortified snacks for daily antioxidant support
Why GreeneryBio
- Uncompromising quality — GMP / ISO-certified production with full traceability from raw material to finished product
- Customization — flexible purity grades (95–99.5%) and packaging options (10 mg to 25 kg)
- Technical expertise — in-house R&D team supports formulation development and stability testing
- Sustainable sourcing — GAP-compliant raw-material bases for long-term supply
- Reliable supply — scalable manufacturing for both small-scale R&D and large commercial orders
- Regulatory compliance — products meet international standards (USP, EP, ICH) for global market access
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
